Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | GSR | P00390 | 1/20 | 0.47 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 2/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | NTSR2 | O95665 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL5886691 | 0.93 | SLC7A5 (0.48) | SLC7A5ITGB3ITGA2BTHRBGSR | |
| Tyrosine SCHEMBL28875441 | 0.89 | SLC7A5 (0.60) | SLC7A5ITGB3ITGA2BTHRBGSR | |
| Tyrosine SCHEMBL28676897 | 0.89 | SLC7A5 (0.60) | SLC7A5ITGB3ITGA2BTHRBGSR | |
| Tyrosine SCHEMBL14247975 | 0.89 | SLC7A5 (0.71) | SLC7A5ACEMMECPA1ACE2 | |
| Tyrosine SCHEMBL1537436 | 0.89 | SLC7A5 (0.71) | SLC7A5ACEMMECPA1ACE2 | |
| Tyrosine SCHEMBL1537442 | 0.89 | SLC7A5 (0.71) | SLC7A5ACEMMECPA1ACE2 | |
| Tyrosine SCHEMBL14562522 | 0.89 | SLC7A5 (0.71) | SLC7A5ACEMMECPA1ACE2 | |
| Tyrosine SCHEMBL2585995 | 0.88 | SLC7A5 (0.50) | SLC7A5ITGB3ITGA2BTHRBGSR | |
| Tyrosine SCHEMBL3513723 | 0.88 | SLC7A5 (0.65) | SLC7A5ITGB3ITGA2BTHRBGSR | |
| Tyrosine SCHEMBL530008 | 0.88 | SLC7A5 (0.65) | SLC7A5ITGB3ITGA2BTHRBGSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063195-B2 | Mutations in a toll-like receptor motif in the NS4B of classical swine fever virus strain brescia influences virulence in swine | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 2011-11-22 | — | — | US | disclosed |
| WO-2010135054-A2 | MUTATIONS IN A TOLL-LIKE RECEPTOR MOTIF IN THE NS4B OF CLASSICAL SWINE FEVER VIRUS SKIN BRESCIA INFLUENCES VIRULENCE IN SWINE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 2010-11-25 | — | — | WO | disclosed |
| US-20100297175-A1 | Mutations in a toll-like receptor motif in the NS4B of classical swine fever virus strain brescia influences virulence in swine | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE | 2010-11-25 | — | — | US | disclosed |