Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 5/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.39 |
| ▸ | PLAUR | Q03405 | 2/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.39 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL2585997 | 0.93 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL29157306 | 0.86 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL28159330 | 0.86 | SLC7A5 (0.58) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL20360870 | 0.86 | SLC7A5 (0.65) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL27496365 | 0.86 | SLC7A5 (0.48) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL9111097 | 0.86 | THRB (0.41) | SLC7A5THRBITGB3ITGA2BGSR | |
| Tyrosine SCHEMBL20857031 | 0.85 | SLC7A5 (0.52) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL27814390 | 0.85 | SLC7A5 (0.57) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL3495947 | 0.85 | SLC7A5 (0.61) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL22654492 | 0.85 | SLC7A5 (0.67) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129060-B1 | Export systems for recombinant proteins | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V (DE) | 2006-10-31 | — | — | US | disclosed |
| EP-0886678-B1 | EXPORT SYSTEMS FOR RECOMBINANT PROTEINS | MAX PLANCK GESELLSCHAFT (DE) | 2005-06-29 | — | — | EP | disclosed |