Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.46 |
| ▸ | MGMT | P16455 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 6/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.40 |
| ▸ | CDK2 | P24941 | 6/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 2/20 | 0.37 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.37 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2402087 | 0.83 | PDPK1 (0.51) | PDPK1GDAMGMTKDRAURKB | |
| SCHEMBL29384383 | 0.81 | PDPK1 (0.53) | PDPK1GDACDK1CCNB1CCNA2 | |
| SCHEMBL25860 | 0.81 | PDPK1 (0.53) | PDPK1GDACDK1CCNB1CCNA2 | |
| SCHEMBL1982409 | 0.80 | PDPK1 (0.51) | PDPK1GDAKDRAURKBCDK1 | |
| SCHEMBL17165348 | 0.79 | GDA (0.53) | PDPK1GDAMGMTKDRAURKB | |
| SCHEMBL23779416 | 0.77 | ALDH1A1 (0.44) | MGMTCYP1A2CDK1CCNB1CCNA2 | |
| SCHEMBL16620498 | 0.76 | PDPK1 (0.50) | PDPK1GDAMGMTKDRAURKB | |
| SCHEMBL2909569 | 0.76 | PDPK1 (0.50) | PDPK1GDAMGMTKDRAURKB | |
| SCHEMBL31239223 | 0.76 | PDPK1 (0.53) | PDPK1GDAMGMTKDRAURKB | |
| SCHEMBL8592144 | 0.76 | PDPK1 (0.53) | PDPK1GDAMGMTKDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106794194-A | Antagonists of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B for the treatment of cancer | 中央研究院 | 2017-05-31 | — | — | CN | disclosed |