Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.74 |
| ▸ | PDE4A | P27815 | 1/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lomustine SCHEMBL3995 | 0.85 | ADRA2A (1.00) | ADRA2APDE4AADRA1ASMN1; SMN2ALDH1A1 | |
| Lomustine SCHEMBL868328 | 0.85 | ADRA2A (1.00) | ADRA2APDE4AADRA1ASMN1; SMN2ALDH1A1 | |
| SCHEMBL25860618 | 0.84 | ALDH1A1 (0.74) | ADRA2APDE4AADRA1ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3342754 | 0.84 | ADRA2A (0.74) | ADRA2APDE4AADRA1ASMN1; SMN2ALDH1A1 | |
| SCHEMBL25860152 | 0.84 | ADRA2A (0.74) | ADRA2APDE4AADRA1ASMN1; SMN2ALDH1A1 | |
| Lomustine SCHEMBL28262197 | 0.83 | ADRA2A (0.94) | ADRA2APDE4AADRA1ASMN1; SMN2ALDH1A1 | |
| Lomustine SCHEMBL28159683 | 0.81 | ADRA2A (0.91) | ADRA2APDE4AADRA1ASMN1; SMN2ALDH1A1 | |
| Lomustine SCHEMBL28123007 | 0.81 | ADRA2A (0.91) | ADRA2APDE4AADRA1ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4634654 | 0.80 | ADRA2A (0.79) | ADRA2APDE4AADRA1ASMN1; SMN2ALDH1A1 | |
| Lomustine SCHEMBL1831239 | 0.79 | ADRA2A (0.86) | ADRA2APDE4AADRA1ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212202-A1 | TREATMENT OF MGMT DEFICIENT CANCER WITH 2-FLUOROETHYL-SUBSTITUTED NITROSOUREAS AND OTHER COMPOUNDS | YALE UNIVERSITY | 2023-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230212202-A1 | TREATMENT OF MGMT DEFICIENT CANCER WITH 2-FLUOROETHYL-SUBSTITUTED NITROSOUREAS AND OTHER COMPOUNDS | MSH2, MGMT, MSH6 | ADRA2A 3990/4885PDE4A 1644/4885ADRA1A 4262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.