⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10306587 | 0.78 | — | — | |
| SCHEMBL9936065 | 0.76 | — | — | |
| SCHEMBL7460269 | 0.76 | — | — | |
| SCHEMBL15800899 | 0.76 | TSHR (0.46) | — | |
| SCHEMBL9131646 | 0.74 | USP2 (0.30) | — | |
| SCHEMBL12916978 | 0.72 | LMNA (0.44) | — | |
| SCHEMBL28406593 | 0.72 | ALDH1A1 (0.38) | — | |
| SCHEMBL12916989 | 0.72 | ALDH1A1 (0.34) | — | |
| SCHEMBL15912147 | 0.70 | GAA (0.48) | — | |
| SCHEMBL28018015 | 0.70 | ALDH1A1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720853-B2 | PHARMACEUTICAL COMPOSITIONS OF THE 2 CRYSTALLINE FORM OF IMATINIB MESYLATE FOR USE IN THE TREATMENT OF CHRONIC MYELOGENOUS LEUKEMIA | NATCO PHARMA LTD (IN) | 2023-06-28 | — | — | EP | disclosed |
| EP-1720853-B1 | NOVEL POLYMORPHIC FORM OF IMATINIB MESYLATE AND A PROCESS FOR ITS PREPARATION | NATCO PHARMA LTD (IN) | 2015-12-30 | — | — | EP | disclosed |
| US-8212012-B2 | Novobiocin analogues having modified sugar moieties | UNIVERSITY OF KANSAS (US) | 2012-07-03 | — | — | US | disclosed |
| US-8212011-B2 | Novobiocin analogues | UNIVERSITY OF KANSAS (US) | 2012-07-03 | — | — | US | disclosed |
| US-8048883-B2 | Chronic Myelogenous Leukemia; crystal form stable at room temperature or higher temperatures up to 120 degrees C. and accelerated stress conditions, freely soluble in water; suspending Imatinib base in isopropanol and adding methane sulfonic acid at room temperature then cooling after reactoion | NATCO PHARMA LIMITED (IN) | 2011-11-01 | — | — | US | disclosed |
| US-7960353-B2 | Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders | UNIVERSITY OF KANSAS (US) | 2011-06-14 | — | — | US | disclosed |
| US-7811998-B2 | Novobiocin analogues as anticancer agents | UNIVERSITY OF KANSAS (US) | 2010-10-12 | — | — | US | disclosed |
| CN-1922134-B | Synthesis of sterically hindered secondary aminoether alcohols | EXXONMOBIL RES & ENG CO | 2010-05-26 | — | — | CN | disclosed |
| US-20100105630-A1 | NOVOBIOCIN ANALOGUES AS NEUROPROTECTIVE AGENTS AND IN THE TREATMENT OF AUTOIMMUNE DISORDERS | UNIVERSITY OF KANSAS (US) | 2010-04-29 | — | — | US | disclosed |
| US-20100048882-A1 | Novobiocin Analogues as Anticancer Agents | UNIVERSITY OF KANSAS (US) | 2010-02-25 | — | — | US | disclosed |
| US-7622451-B2 | Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders | UNIVERSITY OF KANSAS (US) | 2009-11-24 | — | — | US | disclosed |
| US-7608594-B2 | Novobiocin analogues as anticancer agents | UNIVERSITY OF KANSAS (US) | 2009-10-27 | — | — | US | disclosed |
| US-20090187014-A1 | Novobiocin Analogues | UNIVERSITY OF KANSAS | 2009-07-23 | — | — | US | disclosed |
| US-20090163709-A1 | Novobiocin Analogues Having Modified Sugar Moieties | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-06-25 | — | — | US | disclosed |
| US-20080255138-A1 | Novel Polymorphic Form Of Imatinib Mesylate And A Process For Its Preparation | NATCO PHARMA LIMITED (IN) | 2008-10-16 | — | — | US | disclosed |
| US-20070270452-A1 | Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-11-22 | — | — | US | disclosed |
| CN-1922134-A | Synthesis of sterically hindered secondary aminoether alcohols | EXXONMOBIL RES & ENG CO (US) | 2007-02-28 | — | — | CN | disclosed |
| EP-1720853-A1 | NOVEL POLYMORPHIC FORM OF IMATINIB MESYLATE AND A PROCESS FOR ITS PREPARATION | Natco Pharma Limited (IN) | 2006-11-15 | — | — | EP | disclosed |
| WO-2006054314-A1 | POLYMORPHIC FORMS OF IMATINIB MESYLATE | NATCO PHARMA LIMITED (IN) | 2006-05-26 | — | — | WO | disclosed |
| WO-2005077933-A1 | NOVEL POLYMORPHIC FORM OF IMATINIB MESYLATE AND A PROCESS FOR ITS PREPARATION | NATCO PHARMA LIMITED (IN) | 2005-08-25 | — | — | WO | disclosed |