Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.58 |
| ▸ | RECQL | P46063 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.58 |
| ▸ | USP2 | O75604 | 3/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.58 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.58 |
| ▸ | FYN | P06241 | 2/20 | 0.58 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | BLM | P54132 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28036283 | 0.86 | KDM4E (0.67) | ALOX15KDM4EHSD17B10HIF1ARECQL | |
| SCHEMBL12137123 | 0.81 | ALOX15 (0.74) | ALOX15KDM4EHSD17B10HIF1ARECQL | |
| SCHEMBL19565599 | 0.81 | ALOX15 (0.74) | ALOX15KDM4EHSD17B10HIF1ARECQL | |
| SCHEMBL21729924 | 0.81 | ALOX15 (0.74) | ALOX15KDM4EHSD17B10HIF1ARECQL | |
| SCHEMBL1069483 | 0.81 | ALOX15 (0.74) | ALOX15KDM4EHSD17B10HIF1ARECQL | |
| SCHEMBL13661903 | 0.81 | ALOX15 (0.74) | ALOX15KDM4EHSD17B10HIF1ARECQL | |
| SCHEMBL10029410 | 0.81 | ALOX15 (0.74) | ALOX15KDM4EHSD17B10HIF1ARECQL | |
| SCHEMBL20765409 | 0.81 | ALOX15 (0.74) | ALOX15KDM4EHSD17B10HIF1ARECQL | |
| Hydrochloric Acid SCHEMBL20765475 | 0.79 | ALOX15 (0.72) | ALOX15KDM4EHSD17B10HIF1ARECQL | |
| Hydrochloric Acid SCHEMBL20764445 | 0.79 | ALOX15 (0.72) | ALOX15KDM4EHSD17B10HIF1ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048926-B2 | L-DOPA amide derivatives and uses thereof | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2011-11-01 | — | — | US | disclosed |
| EP-1596808-A4 | L-DOPA AMIDE DERIVATIVES AND USES THEREOF | YISSUM RES DEV CO (IL) | 2007-04-04 | — | — | EP | disclosed |
| US-20060025385-A1 | L-DOPA amide derivatives and uses thereof | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2006-02-02 | — | — | US | disclosed |
| EP-1596808-A2 | L-DOPA AMIDE DERIVATIVES AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004069146-A2 | L-DOPA AMIDE DERIVATIVES AND USES THEREOF | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025385-A1 | L-DOPA amide derivatives and uses thereof | SNCA, DBH, PARK7 | ALOX15 1467/4885KDM4E 3395/4885HSD17B10 2592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.