Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2582295 | 0.78 | GAA (0.42) | GAAHTTSMN1; SMN2LMNAPPARG | |
| SCHEMBL4261853 | 0.72 | LMNA (0.48) | GAAHTTSMN1; SMN2MAPTTHRB | |
| SCHEMBL2579238 | 0.72 | SMN1; SMN2 (0.42) | GAAL3MBTL1SMN1; SMN2MAPTTHRB | |
| SCHEMBL2589561 | 0.69 | HSP90AA1 (0.38) | GAAHTTL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL2587146 | 0.69 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL2578732 | 0.68 | LMNA (0.44) | GAAHTTSMN1; SMN2MAPTLMNA | |
| SCHEMBL5533718 | 0.68 | LMNA (0.46) | GAAHTTL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL2582296 | 0.66 | CRHBP (0.44) | GAAHTTMAPTTHRBLMNA | |
| SCHEMBL2579176 | 0.64 | SMN1; SMN2 (0.41) | GAAHTTSMN1; SMN2MAPTLMNA | |
| SCHEMBL629927 | 0.64 | KCNQ1 (0.47) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |