Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261853 | 0.79 | LMNA (0.48) | PKMSMN1; SMN2LMNAGAAPPARG | |
| SCHEMBL2582295 | 0.78 | GAA (0.42) | SMN1; SMN2LMNAGAAPPARGHTT | |
| SCHEMBL2578732 | 0.78 | LMNA (0.44) | SMN1; SMN2LMNAGAAPPARGHTT | |
| SCHEMBL2579238 | 0.76 | SMN1; SMN2 (0.42) | HSP90AA1SMN1; SMN2GAAPPARGL3MBTL1 | |
| SCHEMBL5533718 | 0.74 | LMNA (0.46) | PKMSMN1; SMN2LMNAGAAPPARG | |
| SCHEMBL2586012 | 0.73 | MEN1 (0.47) | HSP90AA1SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL2582296 | 0.71 | CRHBP (0.44) | LMNAGAAPPARGHTTKMT2A | |
| SCHEMBL2585178 | 0.69 | ALDH1A1 (0.47) | SMN1; SMN2LMNAGAAHPGDKMT2A | |
| SCHEMBL5527187 | 0.69 | LMNA (0.43) | PKMSMN1; SMN2LMNAGAAHTT | |
| SCHEMBL2586739 | 0.69 | GAA (0.39) | SMN1; SMN2LMNAGAAPPARGHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |