Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL14715835 | 1.00 | — | — | |
| Maleic Acid SCHEMBL429154 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL7620807 | 1.00 | TSHR (0.90) | — | |
| Maleic Acid SCHEMBL7620797 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL8157540 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL8157542 | 0.95 | TSHR (0.82) | — | |
| Maleic Acid SCHEMBL994743 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL12488514 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL994746 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL12488512 | 0.95 | TSHR (0.82) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 473 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12551425-B2 | Aqueous zinc oral care compositions with fluoride | SOLVENTUM INTELLECTUAL PROPERTIES COMPANY (US) | 2026-02-17 | — | — | US | claimed |
| WO-2025097569-A1 | HYDROGENATION CATALYST, PREPARATION METHOD THEREFOR AND USE THEREOF, AND OIL PRODUCT HYDROTREATING METHOD | 中国石油化工股份有限公司 | 2025-05-15 | — | — | WO | claimed |
| CN-119972121-A | Hydrodenitrogenation catalyst, preparation and application | 中国石油化工股份有限公司 | 2025-05-13 | — | — | CN | claimed |
| EP-3359138-B1 | DIETARY SUPPLEMENTATION TO ACHIEVE OXY-REDOX HOMEOSTASIS AND EPIGENETIC STABILITY | PARTHENOGEN SAGL (CH) | 2024-04-24 | — | — | EP | claimed |
| CN-114287528-B | High-grain low-grain cassava feed and preparation method thereof | 云南省农业科学院热带亚热带经济作物研究所 | 2024-02-06 | — | — | CN | claimed |
| US-20230338261-A1 | AQUEOUS ZINC ORAL CARE COMPOSITIONS WITH FLUORIDE | SOLVENTUM INTELLECTUAL PROPERTIES COMPANY | 2023-10-26 | — | — | US | claimed |
| CN-114836119-B | Preparation method of zinc-doped three-dimensional graphene/hierarchical porous carbon water-based anticorrosive paint | 江苏索普聚酯科技有限公司 | 2023-08-01 | — | — | CN | claimed |
| EP-4084770-B1 | AQUEOUS ZINC ORAL CARE COMPOSITIONS WITH FLUORIDE | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2023-07-19 | — | — | EP | claimed |
| US-20230087246-A1 | DELIVERY SYSTEM FOR AQUEOUS ZINC ORAL CARE COMPOSITIONS WITH FLUORIDE | SOLVENTUM INTELLECTUAL PROPERTIES COMPANY | 2023-03-23 | — | — | US | claimed |
| WO-2023007088-A1 | FOOD SUPPLEMENT FOR COMBATING FEMALE AND MALE INFERTILITY | NURIBIOL (FR) | 2023-02-02 | — | — | WO | claimed |
| EP-0924996-A1 | USE OF BILAYER FORMING EMULSIFIERS IN NUTRITIONAL COMPOSITIONS COMPRISING DIVALENT METAL SALTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-30 | — | — | EP | claimed |
| US-5888563-A | Use of bilayer forming emulsifiers in nutritional compositions comprising divalent mineral salts to minimize off-tastes and interactions with other dietary components | THE PROCTER & GAMBLE COMPANY (US) | 1999-03-30 | — | — | US | claimed |
| WO-1998043486-A1 | METHOD AND COMPOSITIONS FOR STABILIZING SULFHYDRYL PROTEASES | MCCORMICK & COMPANY, INC. (US) | 1998-10-08 | — | — | WO | claimed |
| WO-1998008401-A1 | USE OF BILAYER FORMING EMULSIFIERS IN NUTRITIONAL COMPOSITIONS COMPRISING DIVALENT METAL SALTS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-05 | — | — | WO | claimed |
| CN-1145187-A | Compounded premixed feed for pig | WANG ZHIDONG (CN) | 1997-03-19 | — | — | CN | claimed |
| EP-0173568-B1 | ORAL COMPOSITIONS | Johnson & Johnson Products Inc. (US) | 1990-10-24 | — | — | EP | claimed |
| US-4863987-A | Deodorizing coating formulations and deodorizing sheets making use of same | DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD. (JP) | 1989-09-05 | — | — | US | claimed |
| US-4664906-A | SYNERGISTIC MIXTURE OF HEXEDINE AND ZINC SALT | JOHNSON & JOHNSON PRODUCTS INC. (US) | 1987-05-12 | — | — | US | claimed |
| EP-0173568-A2 | Oral compositions | Johnson & Johnson Products Inc. (US) | 1986-03-05 | — | — | EP | claimed |
| US-3996142-A | Smoke and fire retardants for halogen-containing plastic compositions comprising the reaction product of magnesium oxide and a zinc salt of an acid | NL INDUSTRIES, INC. (US) | 1976-12-07 | — | — | US | claimed |