Fumaric Acid

Fumaric Acid

SCHEMBL994746

N.O=C(O)C=CC(=O)O.[Zn]

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol

The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A known ✓ Q03164 2/20 0.39
MEN1 known ✓ O00255 1/20 0.39
TSHR P16473 4/20 0.82
TP53 P04637 1/20 0.82
EGLN1 Q9GZT9 1/20 0.82
EGLN3 Q9H6Z9 1/20 0.82
HCAR2 Q8TDS4 4/20 0.47
GABRR1 P24046 2/20 0.42
GABRR2 P28476 2/20 0.42
BLM P54132 2/20 0.42
TDP1 Q9NUW8 2/20 0.42
LMNA P02545 2/20 0.42
GABRR3 A8MPY1 1/20 0.42
APEX1 P27695 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
ALDH1A1 P00352 3/20 0.41
GAA P10253 1/20 0.41
ALOX15 P16050 1/20 0.41
RECQL P46063 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Maleic Acid SCHEMBL994743 1.00 TSHR (0.82) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL6466117 0.95 TSHR (0.90) TSHRTP53EGLN1EGLN3HCAR2
Maleic Acid SCHEMBL716254 0.95
Fumaric Acid SCHEMBL41494 0.95 TSHR (0.90) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL41492 0.95
Maleic Acid SCHEMBL429154 0.95
Fumaric Acid SCHEMBL6466120 0.95 TSHR (0.90) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL14715835 0.95
Fumaric Acid SCHEMBL41491 0.95 TSHR (0.90) TSHRTP53EGLN1EGLN3HCAR2
Fumaric Acid SCHEMBL7620807 0.95 TSHR (0.90) TSHRTP53EGLN1EGLN3HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0861302-B1 COATABLE BIOCIDAL COMPOSITIONS MINNESOTA MINING & MFG (US) 2001-11-07 EP claimed
EP-0861302-A1 COATABLE BIOCIDAL COMPOSITIONS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1998-09-02 EP claimed
WO-1997003135-A1 COATABLE BIOCIDAL COMPOSITIONS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-01-30 WO claimed
US-5585407-A SUSTAINED RELEASE OF MICROBIOCIDES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-12-17 US claimed
CN-110655871-A Polymer composition containing silane groups and coatings containing the same 欧美诺华解决方案公司 2020-01-07 CN disclosed
US-10259928-B2 Silane group-containing polymer composition and coatings containing same OMNOVA SOLUTIONS INC. (US) 2019-04-16 US disclosed
US-10253202-B2 Protective coating compositions OMNOVA SOLUTIONS INC. (US) 2019-04-09 US disclosed
US-20170226368-A9 PROTECTIVE COATING COMPOSITIONS SYNTHOMER INC. 2017-08-10 US disclosed
US-9668476-B2 Removable antimicrobial coating compositions and methods of use LANXESS CORPORATION (US) 2017-06-06 US disclosed
US-20160286796-A1 REMOVABLE COATING COMPOSITION THE CHEMOURS COMPANY FC, LLC 2016-10-06 US disclosed
US-20160185997-A1 PROTECTIVE COATING COMPOSITIONS GLAS TRUST CORPORATION LIMITED, AS SECURITY AGENT (GB) 2016-06-30 US disclosed
US-8940826-B2 Protective coating compositions OMNOVA SOLUTIONS INC. (US) 2015-01-27 US disclosed
US-20080026026-A1 Removable antimicrobial coating compositions and methods of use THE CHEMOURS COMPANY FC, LLC 2008-01-31 US disclosed
US-20070275101-A1 Removable antimicrobial coating compositions and methods of use THE CHEMOURS COMPANY FC, LLC 2007-11-29 US disclosed
WO-2007100654-A2 REMOVABLE ANTIMICROBIAL COATING COMPOSITIONS AND METHODS OF USE E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-09-07 WO disclosed
WO-2007100653-A2 REMOVABLE ANTIMICROBIAL COATING COMPOSITIONS AND METHODS OF USE E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-09-07 WO disclosed
EP-0861302-B1 COATABLE BIOCIDAL COMPOSITIONS MINNESOTA MINING & MFG (US) 2001-11-07 EP disclosed
EP-0861302-A1 COATABLE BIOCIDAL COMPOSITIONS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1998-09-02 EP disclosed
WO-1997003135-A1 COATABLE BIOCIDAL COMPOSITIONS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-01-30 WO disclosed
US-5585407-A SUSTAINED RELEASE OF MICROBIOCIDES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-12-17 US disclosed