Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL258677 | 1.00 | — | — | |
| Maleic Acid SCHEMBL429154 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL7620807 | 1.00 | TSHR (0.90) | — | |
| Maleic Acid SCHEMBL7620797 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL8157540 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL8157542 | 0.95 | TSHR (0.82) | — | |
| Maleic Acid SCHEMBL994743 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL12488514 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL994746 | 0.95 | TSHR (0.82) | — | |
| Fumaric Acid SCHEMBL12488512 | 0.95 | TSHR (0.82) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115322482-A | High-impact-resistance and high-fluidity homo-polypropylene material and preparation method thereof | 北方华锦化学工业股份有限公司 | 2022-11-11 | — | — | CN | claimed |
| US-20220193497-A1 | METALLIC MONOMER USED AS IONOMERIC ADDITIVES FOR IONOMERS AND POLYOLEFINS | TAYLOR MADE GOLF COMPANY, INC. (US) | 2022-06-23 | — | — | US | claimed |
| US-20200078642-A1 | METALLIC MONOMER USED AS IONOMERIC ADDITIVES FOR IONOMERS AND POLYOLEFINS | TAYLOR MADE GOLF COMPANY, INC. | 2020-03-12 | — | — | US | claimed |
| CN-106893138-B | PVC laurene source composite thermal stabilizer and its preparation method and application | 中国林业科学研究院林产化学工业研究所 | 2019-03-29 | — | — | CN | claimed |
| CN-107313291-A | A kind of preparation method of anti-corrosion corrugated paper | 天津碧宇舟机械制造有限公司 | 2017-11-03 | — | — | CN | claimed |
| CN-106893138-A | PVC laurene source composite thermal stabilizers and its preparation method and application | 中国林业科学研究院林产化学工业研究所 | 2017-06-27 | — | — | CN | claimed |
| US-20160354645-A1 | METALLIC MONOMER USED AS IONOMERIC ADDITIVES FOR IONOMERS AND POLYOLEFINS | TAYLOR MADE GOLF COMPANY, INC. (US) | 2016-12-08 | — | — | US | claimed |
| CN-103289282-B | A kind of cable jacket material containing modified polyphenylene ether resin and preparation method thereof | ANHUI GREEN ECOLOGICAL POLYMER MATERIALS TECHNOLOGY CO., LTD. (CN) | 2015-10-07 | — | — | CN | claimed |
| CN-104594113-A | Corrugated paper containing modified polyphenyl ether resin and preparation method of corrugated paper | HANGZHOU DANSUN PACKGING CO LTD | 2015-05-06 | — | — | CN | claimed |
| EP-2748244-A1 | METAL CARBOXYLATE ADDITIVES FOR THERMOPLASTICS | Total Petrochemicals & Refining USA, Inc. (US) | 2014-07-02 | — | — | EP | claimed |
| CN-103289282-A | Cable sheath material containing modified poly-phenyl ether resin and preparation method thereof | ANHUI GREEN ECOLOGICAL POLYMER MATERIALS TECHNOLOGY CO LTD | 2013-09-11 | — | — | CN | claimed |
| US-20130053496-A1 | METAL CARBOXYLATE ADDITIVES FOR THERMOPLASTICS | CRAY VALLEY TECHNOLOGY USA, LLC (US) | 2013-02-28 | — | — | US | claimed |
| WO-2013028485-A1 | METAL CARBOXYLATE ADDITIVES FOR THERMOPLASTICS | CRAY VALLEY TECHNOLOGY USA, LLC (US) | 2013-02-28 | — | — | WO | claimed |
| CN-102070857-B | Calcium-zinc compound stabilizer for polyvinyl chloride (PVC) and preparation method of calcium-zinc compound stabilizer | UNIV SOUTHWEST | 2012-02-01 | — | — | CN | claimed |
| CN-102070858-B | Sodium-zinc compound stabilizer for PVC and preparation method thereof | UNIV SOUTHWEST | 2012-02-01 | — | — | CN | claimed |
| CN-102070857-A | Calcium-zinc compound stabilizer for polyvinyl chloride (PVC) and preparation method of calcium-zinc compound stabilizer | UNIV SOUTHWEST | 2011-05-25 | — | — | CN | claimed |
| CN-102070858-A | Sodium-zinc compound stabilizer for PVC and preparation method thereof | UNIV SOUTHWEST | 2011-05-25 | — | — | CN | claimed |
| CN-1008792-B | Oral composition | ZHUNGCHEN NECESSITIES CO (US) | 1990-07-18 | — | — | CN | claimed |
| CN-85103393-A | MIXTURE FOR MOUTH | — | 1986-12-03 | — | — | CN | claimed |
| CN-120040222-A | Macroelement solid fertilizer and preparation method thereof by using temperature difference phase separation method | 河北协同化学有限公司 | 2025-05-27 | — | — | CN | disclosed |
| CN-114989542-B | PVC modified silica gel hose and production process thereof | 浙江新洁新材料科技有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-114989542-A | PVC modified silica gel hose and production process thereof | 浙江新洁新材料科技有限公司 | 2022-09-02 | — | — | CN | disclosed |
| US-20220193497-A1 | METALLIC MONOMER USED AS IONOMERIC ADDITIVES FOR IONOMERS AND POLYOLEFINS | TAYLOR MADE GOLF COMPANY, INC. (US) | 2022-06-23 | — | — | US | disclosed |
| US-20200078642-A1 | METALLIC MONOMER USED AS IONOMERIC ADDITIVES FOR IONOMERS AND POLYOLEFINS | TAYLOR MADE GOLF COMPANY, INC. | 2020-03-12 | — | — | US | disclosed |
| CN-109705272-A | Microspheroidal ionomer with cross-linked structure and its preparation method and application | 中国石油化工股份有限公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-109705539-A | Composition containing polyethylene terephthalate and the method for preparing plastic alloy | 中国石油化工股份有限公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-109705251-A | Microspheroidal ionomer with cross-linked structure and its preparation method and application | 中国石油化工股份有限公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-106893138-B | PVC laurene source composite thermal stabilizer and its preparation method and application | 中国林业科学研究院林产化学工业研究所 | 2019-03-29 | — | — | CN | disclosed |
| CN-107313291-A | A kind of preparation method of anti-corrosion corrugated paper | 天津碧宇舟机械制造有限公司 | 2017-11-03 | — | — | CN | disclosed |
| CN-107313291-A | A kind of preparation method of anti-corrosion corrugated paper | 天津碧宇舟机械制造有限公司 | 2017-11-03 | — | — | CN | disclosed |
| EP-2748244-B1 | METAL CARBOXYLATE ADDITIVES FOR THERMOPLASTICS | TOTAL PETROCHEMICALS & REFINING USA INC (US) | 2017-09-27 | — | — | EP | disclosed |
| CN-106893138-A | PVC laurene source composite thermal stabilizers and its preparation method and application | 中国林业科学研究院林产化学工业研究所 | 2017-06-27 | — | — | CN | disclosed |
| CN-106519127-A | Method for preparing calcium-zinc epoxy copolymer core-shell emulsion and modified wood plastic material | 贵州华锐达环保装饰材料有限公司 | 2017-03-22 | — | — | CN | disclosed |
| US-20160354645-A1 | METALLIC MONOMER USED AS IONOMERIC ADDITIVES FOR IONOMERS AND POLYOLEFINS | TAYLOR MADE GOLF COMPANY, INC. (US) | 2016-12-08 | — | — | US | disclosed |
| CN-103289282-B | A kind of cable jacket material containing modified polyphenylene ether resin and preparation method thereof | ANHUI GREEN ECOLOGICAL POLYMER MATERIALS TECHNOLOGY CO., LTD. (CN) | 2015-10-07 | — | — | CN | disclosed |
| CN-103289282-B | A kind of cable jacket material containing modified polyphenylene ether resin and preparation method thereof | ANHUI GREEN ECOLOGICAL POLYMER MATERIALS TECHNOLOGY CO., LTD. (CN) | 2015-10-07 | — | — | CN | disclosed |
| US-9045615-B2 | Metal carboxylate additives for thermoplastics | FINA TECHNOLOGY, INC. (US) | 2015-06-02 | — | — | US | disclosed |
| CN-104594113-A | Corrugated paper containing modified polyphenyl ether resin and preparation method of corrugated paper | HANGZHOU DANSUN PACKGING CO LTD | 2015-05-06 | — | — | CN | disclosed |
| CN-104582697-A | Antibacterial microelement chelates and the use thereof in animal feeds | BATA ZRT DR | 2015-04-29 | — | — | CN | disclosed |
| EP-2748244-A1 | METAL CARBOXYLATE ADDITIVES FOR THERMOPLASTICS | Total Petrochemicals & Refining USA, Inc. (US) | 2014-07-02 | — | — | EP | disclosed |
| CN-103289282-A | Cable sheath material containing modified poly-phenyl ether resin and preparation method thereof | ANHUI GREEN ECOLOGICAL POLYMER MATERIALS TECHNOLOGY CO LTD | 2013-09-11 | — | — | CN | disclosed |
| CN-103289282-A | Cable sheath material containing modified poly-phenyl ether resin and preparation method thereof | ANHUI GREEN ECOLOGICAL POLYMER MATERIALS TECHNOLOGY CO LTD | 2013-09-11 | — | — | CN | disclosed |
| US-20130053496-A1 | METAL CARBOXYLATE ADDITIVES FOR THERMOPLASTICS | CRAY VALLEY TECHNOLOGY USA, LLC (US) | 2013-02-28 | — | — | US | disclosed |
| WO-2013028485-A1 | METAL CARBOXYLATE ADDITIVES FOR THERMOPLASTICS | CRAY VALLEY TECHNOLOGY USA, LLC (US) | 2013-02-28 | — | — | WO | disclosed |
| CN-202490612-U | Continuous production device for depolymerizing waste polyurethane and regenerating polyatomic alcohol | GUANGZHOU PA CHEMICAL LTD | 2012-10-17 | — | — | CN | disclosed |
| CN-1966563-B | Beta-crystal form polypropylene nucleating agent and polypropylene resin composition containing same | UNIV EAST CHINA SCIENCE & TECH | 2012-04-25 | — | — | CN | disclosed |
| CN-102070858-B | Sodium-zinc compound stabilizer for PVC and preparation method thereof | UNIV SOUTHWEST | 2012-02-01 | — | — | CN | disclosed |
| CN-102070857-B | Calcium-zinc compound stabilizer for polyvinyl chloride (PVC) and preparation method of calcium-zinc compound stabilizer | UNIV SOUTHWEST | 2012-02-01 | — | — | CN | disclosed |
| CN-102070858-B | Sodium-zinc compound stabilizer for PVC and preparation method thereof | UNIV SOUTHWEST | 2012-02-01 | — | — | CN | disclosed |
| CN-102070858-A | Sodium-zinc compound stabilizer for PVC and preparation method thereof | UNIV SOUTHWEST | 2011-05-25 | — | — | CN | disclosed |
| CN-102070857-A | Calcium-zinc compound stabilizer for polyvinyl chloride (PVC) and preparation method of calcium-zinc compound stabilizer | UNIV SOUTHWEST | 2011-05-25 | — | — | CN | disclosed |
| CN-102070858-A | Sodium-zinc compound stabilizer for PVC and preparation method thereof | UNIV SOUTHWEST | 2011-05-25 | — | — | CN | disclosed |
| CN-1966563-A | Beta crystal form polypropylene nucleating agent and polypropylene resin composition containing same | UNIV EAST CHINA SCIENCE & TECH (CN) | 2007-05-23 | — | — | CN | disclosed |
| CN-1109700-C | Polyisocyanate composition and use thereof | HUNTSMAN ICI CHEM LLC (US) | 2003-05-28 | — | — | CN | disclosed |
| CN-1095403-C | Process for preparing zinc bicarboxylate catalyst | GUANGZHOU INST OF CHEMISTRY (CN) | 2002-12-04 | — | — | CN | disclosed |
| CN-1302694-A | Process for preparing zinc bicarboxylate catalyst | GUANGZHOU INST OF CHEMISTRY (CN) | 2001-07-11 | — | — | CN | disclosed |
| CN-1201469-A | Polyisocyantates composition | ICI PLC (GB) | 1998-12-09 | — | — | CN | disclosed |
| CN-1008792-B | Oral composition | ZHUNGCHEN NECESSITIES CO (US) | 1990-07-18 | — | — | CN | disclosed |
| CN-85103393-A | MIXTURE FOR MOUTH | — | 1986-12-03 | — | — | CN | disclosed |
| CN-85103393-A | MIXTURE FOR MOUTH | — | 1986-12-03 | — | — | CN | disclosed |