Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2590439 | 0.83 | GPR119 (0.42) | ATM | |
| SCHEMBL2586785 | 0.83 | SMN1; SMN2 (0.48) | — | |
| SCHEMBL2595591 | 0.82 | EPHX2 (0.39) | EPHX2CYP2C9PTPN11EPHX1SIGMAR1 | |
| SCHEMBL14972719 | 0.81 | EPHX2 (0.38) | EPHX2CYP2C9EPHX1SIGMAR1SCN5A | |
| SCHEMBL14972718 | 0.81 | EPHX2 (0.38) | EPHX2CYP2C9EPHX1SIGMAR1SCN5A | |
| SCHEMBL2590155 | 0.76 | KMT2A (0.35) | EPHX2CYP2C9SIGMAR1ATMHRH3 | |
| SCHEMBL21383845 | 0.74 | HDAC3 (0.48) | EPHX2CYP2C9SIGMAR1 | |
| SCHEMBL3222598 | 0.73 | SIGMAR1 (0.66) | EPHX2CYP2C9EPHX1SIGMAR1SCN5A | |
| SCHEMBL2588053 | 0.73 | SIGMAR1 (0.66) | EPHX2CYP2C9EPHX1SIGMAR1SCN5A | |
| SCHEMBL12542376 | 0.71 | LMNA (0.36) | EPHX2PTPN11EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595989-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2013067248-A1 | BENZOXAZINES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-05-10 | — | — | WO | disclosed |
| WO-2011140425-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-10 | — | — | WO | disclosed |