Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2596043 | 0.85 | GPR119 (0.41) | ALOX15ATMKDM4ETSHR | |
| SCHEMBL2586822 | 0.82 | EPHX2 (0.40) | EPHX2CYP2C9ATMEPHX1SCN5A | |
| SCHEMBL14972718 | 0.81 | EPHX2 (0.38) | EPHX2CYP2C9CYP3A4ALOX15ATM | |
| SCHEMBL14972719 | 0.79 | EPHX2 (0.38) | EPHX2CYP2C9ATMEPHX1SCN5A | |
| SCHEMBL2590155 | 0.77 | KMT2A (0.35) | EPHX2CYP2C9CYP3A4ALOX15ATM | |
| SCHEMBL21383845 | 0.72 | HDAC3 (0.48) | EPHX2CYP2C9SIGMAR1 | |
| SCHEMBL2589311 | 0.72 | OPRD1 (0.44) | OPRD1KCNH2ALDH1A1 | |
| SCHEMBL3222598 | 0.71 | SIGMAR1 (0.66) | EPHX2CYP2C9ATMEPHX1SCN5A | |
| SCHEMBL2588053 | 0.71 | SIGMAR1 (0.66) | EPHX2CYP2C9ATMEPHX1SCN5A | |
| SCHEMBL3492775 | 0.71 | GPR119 (0.43) | ALOX15ATMKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595989-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2011140425-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-10 | — | — | WO | disclosed |