Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.57 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.57 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.57 |
| ▸ | TDP2 | O95551 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | BRD2 | P25440 | 1/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | PAK4 | O96013 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10389918 | 0.98 | MAP4K4 (0.59) | KMOMAPTSMN1; SMN2MAP4K4CSNK1G2 | |
| SCHEMBL407605 | 0.96 | KMO (0.67) | KMOMAPTSMN1; SMN2MAP4K4CSNK1G2 | |
| SCHEMBL29446517 | 0.96 | KMO (0.67) | KMOMAPTSMN1; SMN2MAP4K4CSNK1G2 | |
| SCHEMBL10389377 | 0.94 | MAPT (0.69) | KMOMAPTSMN1; SMN2MAP4K4CSNK1G2 | |
| SCHEMBL2786037 | 0.90 | HSD17B1 (0.64) | KMOMAPTSMN1; SMN2TDP2PGR | |
| SCHEMBL4572428 | 0.90 | NPC1 (0.56) | KMOMAPTSMN1; SMN2MAP4K4CSNK1G2 | |
| SCHEMBL3015814 | 0.89 | KMO (0.70) | KMOMAPTSMN1; SMN2MAP4K4CSNK1G2 | |
| SCHEMBL29951818 | 0.89 | KMO (0.70) | KMOMAPTSMN1; SMN2MAP4K4CSNK1G2 | |
| SCHEMBL23289052 | 0.88 | DHODH (0.58) | KMOMAPTSMN1; SMN2MAP4K4CSNK1G2 | |
| SCHEMBL23289053 | 0.88 | KMT2A (0.63) | KMOMAPTSMN1; SMN2TDP2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571879-A1 | HETEROBIARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011134877-A1 | HETEROBIARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-03 | — | — | WO | disclosed |