Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 3/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.30 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | ITGAL | P20701 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30499640 | 0.85 | LMNA (0.39) | USP30TGFBR1ACVR1BACVRL1POLB | |
| SCHEMBL25306410 | 0.85 | LMNA (0.39) | USP30TGFBR1ACVR1BACVRL1POLB | |
| SCHEMBL25869192 | 0.83 | WNT3A (0.37) | TGFBR1ACVR1BACVRL1 | |
| SCHEMBL25130973 | 0.82 | TGFBR1 (0.38) | TGFBR1ACVRL1CYP3A4LMNAMAPT | |
| SCHEMBL25130851 | 0.81 | TGFBR1 (0.38) | TGFBR1ACVR1BACVRL1CYP3A4LMNA | |
| SCHEMBL25131855 | 0.81 | TGFBR1 (0.38) | TGFBR1ACVRL1CYP3A4LMNAMAPT | |
| SCHEMBL25131836 | 0.81 | TGFBR1 (0.35) | TGFBR1ACVR1BACVRL1CYP3A4MAPT | |
| SCHEMBL25130826 | 0.80 | TGFBR1 (0.37) | TGFBR1ACVRL1CYP3A4LMNAMAPT | |
| SCHEMBL25130880 | 0.80 | EGFR (0.36) | TGFBR1CYP3A4ITGB2ICAM1ITGAL | |
| SCHEMBL25130831 | 0.79 | TGFBR1 (0.35) | TGFBR1ACVR1BACVRL1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023135107-A1 | PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2023-07-20 | — | — | WO | disclosed |