Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 2/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | XPO1 | O14980 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588804 | 0.88 | RIPK1 (0.44) | RIPK1ALDH1A1PDE5AMAOAMAOB | |
| SCHEMBL3628133 | 0.88 | STS (0.39) | RIPK1STSFFAR2 | |
| SCHEMBL2581199 | 0.88 | STS (0.39) | RIPK1STSFFAR2 | |
| SCHEMBL4520273 | 0.86 | FFAR2 (0.45) | RIPK1FFAR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4520271 | 0.86 | FFAR2 (0.45) | RIPK1FFAR2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL28527618 | 0.86 | RIPK1 (0.45) | RIPK1STSFFAR2SMN1; SMN2PDE5A | |
| SCHEMBL2581640 | 0.85 | FFAR2 (0.39) | RIPK1FFAR2ALDH1A1 | |
| SCHEMBL2584569 | 0.85 | FFAR2 (0.39) | RIPK1FFAR2ALDH1A1 | |
| SCHEMBL2583332 | 0.81 | RIPK1 (0.37) | RIPK1FFAR2 | |
| SCHEMBL2588030 | 0.81 | FFAR2 (0.39) | RIPK1FFAR2SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048878-B2 | Two cyclic cinnamide compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-11-01 | — | — | US | disclosed |