Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.59 |
| ▸ | EGFR | P00533 | 4/20 | 0.59 |
| ▸ | INSR | P06213 | 5/20 | 0.56 |
| ▸ | IGF1R | P08069 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.53 |
| ▸ | MET | P08581 | 2/20 | 0.53 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.53 |
| ▸ | CDC7 | O00311 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26495709 | 0.90 | EGFR (0.67) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL25871927 | 0.89 | ALK (0.62) | ALKEGFRINSRIGF1RCYP3A4 | |
| Hydrochloric Acid SCHEMBL25261966 | 0.89 | EGFR (0.66) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL25871978 | 0.89 | ALK (0.60) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL25872148 | 0.88 | ALK (0.73) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL25872145 | 0.87 | ALK (0.66) | ALKEGFR | |
| SCHEMBL29059803 | 0.85 | ALK (0.62) | ALKEGFRINSRIGF1RMAPK8 | |
| SCHEMBL25870332 | 0.85 | ALK (0.60) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL25869800 | 0.83 | ALK (0.75) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL25870490 | 0.83 | ALK (0.58) | ALKEGFRINSRIGF1RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4212522-A1 | COMPOUNDS FOR SUPPRESSING EGFR MUTANT CANCER AND PHARMACEUTICAL USE THEREOF | J2H Biotech Inc. (KR) | 2023-07-19 | — | — | EP | disclosed |