Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 2/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19851208 | 0.87 | OPRL1 (0.45) | ALDH1A1CYP3A4CYP2C9HSD17B10GRIN1 | |
| SCHEMBL25314026 | 0.78 | POLB (0.40) | ALDH1A1POLB | |
| SCHEMBL19851191 | 0.76 | SIGMAR1 (0.45) | ALDH1A1CYP3A4CYP2C9HSD17B10SIGMAR1 | |
| SCHEMBL19839200 | 0.76 | SIGMAR1 (0.45) | ALDH1A1CYP3A4CYP2C9HSD17B10SIGMAR1 | |
| SCHEMBL518379 | 0.74 | ALDH1A1 (0.44) | ALDH1A1POLBCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL25312196 | 0.72 | KDM1A (0.42) | ALDH1A1POLBOPRD1OPRK1 | |
| SCHEMBL19839005 | 0.71 | ALDH1A1 (0.47) | ALDH1A1POLBAKR1B1CYP3A4CYP2C9 | |
| SCHEMBL1555927 | 0.70 | SLC6A9 (0.50) | HSD17B10GRIN1GRIN2AGRIN2BOPRM1 | |
| SCHEMBL21225679 | 0.70 | ALDH1A1 (0.42) | ALDH1A1POLBRAB9AOPRM1 | |
| SCHEMBL5353756 | 0.69 | OPRL1 (0.45) | ALDH1A1CYP1A2CYP3A4CYP2C9OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230210851-A1 | SPIRO-LACTAM COMPOUNDS AND METHODS OF TREATING VIRAL INFECTIONS USING THE SAME | APTINYX INC (US) | 2023-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230210851-A1 | SPIRO-LACTAM COMPOUNDS AND METHODS OF TREATING VIRAL INFECTIONS USING THE SAME | ACE, ACE2, PREP | ALDH1A1 1618/4885POLB 3030/4885AKR1B1 1511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.