Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1293336 | 0.84 | GRM5 (0.45) | GRM5KDM4EALDH1A1 | |
| SCHEMBL3400652 | 0.77 | MCL1 (0.41) | GRM5CYP1A2CYP3A4KITHRH1 | |
| SCHEMBL2591378 | 0.76 | KMT2A (0.41) | GRM5CYP1A2CYP3A4KDM4EALDH1A1 | |
| SCHEMBL14732158 | 0.75 | MEN1 (0.34) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1293181 | 0.75 | SRD5A2 (0.32) | — | |
| SCHEMBL1293824 | 0.74 | SIGMAR1 (0.37) | HRH1HRH2KDM4EALDH1A1MEN1 | |
| SCHEMBL4664913 | 0.70 | HRH1 (0.36) | GRM5KITHRH1SLC6A15KDM4E | |
| SCHEMBL2591372 | 0.69 | — | — | |
| SCHEMBL6382839 | 0.69 | GRM5 (0.47) | GRM5KDM4E | |
| SCHEMBL1293136 | 0.69 | PNMT (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563785-A1 | COMPOUNDS AS AGONISTS OF S1P1 RECEPTORS | Glaxo Group Limited (GB) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134280-A1 | COMPOUNDS AS AGONISTS OF S1P1 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2011-11-03 | — | — | WO | disclosed |