Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | OGA | O60502 | 3/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.33 |
| ▸ | EP300 | Q09472 | 2/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591378 | 0.86 | KMT2A (0.41) | MEN1KMT2AS1PR1ALDH1A1KDM4E | |
| SCHEMBL1293181 | 0.80 | SRD5A2 (0.32) | EP300CARM1 | |
| SCHEMBL1293824 | 0.80 | SIGMAR1 (0.37) | MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL14732194 | 0.78 | S1PR5 (0.34) | OGAS1PR1S1PR3S1PR5 | |
| SCHEMBL1293336 | 0.78 | GRM5 (0.45) | ALDH1A1KDM4E | |
| SCHEMBL2587701 | 0.75 | GRM5 (0.39) | MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL1293136 | 0.73 | PNMT (0.34) | — | |
| SCHEMBL2591372 | 0.71 | — | — | |
| SCHEMBL1293137 | 0.66 | LMNA (0.41) | MEN1KMT2AALDH1A1 | |
| SCHEMBL16956377 | 0.66 | GABRA1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563785-A1 | COMPOUNDS AS AGONISTS OF S1P1 RECEPTORS | Glaxo Group Limited (GB) | 2013-03-06 | — | — | EP | disclosed |
| US-8389508-B2 | Heterocyclic compounds | GLAXO GROUP LIMITED (GB) | 2013-03-05 | — | — | US | disclosed |