Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30936627 | 0.95 | MAPK1 (0.46) | MAPK1ALDH1A1TDP1L3MBTL1CASP7 | |
| SCHEMBL12028784 | 0.86 | MAPK1 (0.44) | MAPK1ALDH1A1TDP1L3MBTL1CASP7 | |
| SCHEMBL25877386 | 0.84 | MAPK1 (0.47) | MAPK1ALDH1A1TDP1L3MBTL1CASP7 | |
| SCHEMBL3958147 | 0.81 | HTT (0.44) | MAPK1ALDH1A1TDP1L3MBTL1CASP7 | |
| SCHEMBL4546434 | 0.80 | MAPK1 (0.41) | MAPK1ALDH1A1TDP1L3MBTL1CASP7 | |
| SCHEMBL15006839 | 0.79 | MAPK1 (0.60) | MAPK1ALDH1A1TDP1L3MBTL1MAPT | |
| SCHEMBL1271748 | 0.77 | PDK1 (0.44) | MAPK1ALDH1A1TDP1L3MBTL1MAPT | |
| SCHEMBL28784770 | 0.76 | PDK1 (0.41) | MAPK1ALDH1A1TDP1L3MBTL1CASP7 | |
| SCHEMBL550289 | 0.75 | ALDH1A1 (0.49) | MAPK1ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL103504 | 0.74 | HCAR3 (0.55) | MAPK1ALDH1A1TDP1L3MBTL1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | FEN1, ERCC4, DCLRE1B | MAPK1 3534/4885ALDH1A1 1451/4885TDP1 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.