Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24123722 | 0.82 | CYP4F2 (0.35) | CYP4F2CYP4A11NR3C1EPAS1MEN1 | |
| SCHEMBL25878288 | 0.76 | NR3C1 (0.34) | NR3C1MEN1KMT2ANR3C2 | |
| SCHEMBL13131958 | 0.73 | KDM4E (0.36) | CYP4F2CYP4A11 | |
| SCHEMBL25877357 | 0.73 | NR3C1 (0.31) | NR3C1 | |
| SCHEMBL3517975 | 0.63 | CYP1A2 (0.50) | CYP4F2CYP4A11 | |
| SCHEMBL8499490 | 0.62 | CYP1A2 (0.48) | CYP4F2CYP4A11 | |
| SCHEMBL12711141 | 0.61 | KDM4E (0.42) | — | |
| SCHEMBL2172046 | 0.60 | LIPE (0.41) | — | |
| SCHEMBL16632605 | 0.60 | CA2 (0.35) | CYP4F2CYP4A11EPAS1MEN1KMT2A | |
| SCHEMBL1458089 | 0.59 | CYP4F2 (0.39) | CYP4F2CYP4A11MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234965-A1 | N-LINKED MACROCYCLIC 4-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | JANSSEN PHARMACEUTICA NV (BE) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234965-A1 | N-LINKED MACROCYCLIC 4-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | MCL1, BCL2L1, BAK1 | CYP4F2 4662/4885CYP4A11 4505/4885NR3C1 2030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.