Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | CASP1 | P29466 | 2/20 | 0.50 |
| ▸ | CASP7 | P55210 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13579042 | 0.78 | KDM4E (0.51) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL20186115 | 0.77 | DYRK1A (0.54) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL13351196 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL15473778 | 0.75 | MET (0.39) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL14116548 | 0.73 | RAB9A (0.62) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL1202800 | 0.72 | ALDH1A1 (0.49) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL24697495 | 0.69 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10RAB9ANPC1 | |
| SCHEMBL31540362 | 0.69 | KDM4E (0.50) | KDM4EALDH1A1HSD17B10RAB9ANPC1 | |
| SCHEMBL13714580 | 0.69 | KDM4E (0.53) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL2066202 | 0.69 | NPC1 (0.37) | KDM4ERAB9ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563792-A1 | IMIDAZOPYRIDAZINYL COMPOUNDS AND THEIR USES FOR CANCER | Bristol-Myers Squibb Company (US) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011137155-A1 | IMIDAZOPYRIDAZINYL COMPOUNDS AND THEIR USES FOR CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-11-03 | — | — | WO | disclosed |