Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.53 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.42 |
| ▸ | CDK2 | P24941 | 6/20 | 0.42 |
| ▸ | CDK7 | P50613 | 6/20 | 0.42 |
| ▸ | CCNH | P51946 | 6/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.42 |
| ▸ | CCNK | O75909 | 5/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | VNN1 | O95497 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25879889 | 0.87 | HRH4 (0.50) | HRH4MAP3K5CDK2HRH3 | |
| SCHEMBL25882002 | 0.78 | EGFR (0.48) | MAP3K5AXLCCNA2CDK2 | |
| SCHEMBL30512114 | 0.78 | EGFR (0.48) | MAP3K5AXLCCNA2CDK2 | |
| SCHEMBL25881961 | 0.78 | MAP3K5 (0.54) | MAP3K5CDK2 | |
| SCHEMBL30512136 | 0.78 | MAP3K5 (0.54) | MAP3K5CDK2 | |
| SCHEMBL30512112 | 0.77 | MAP3K5 (0.54) | MAP3K5CDK2 | |
| SCHEMBL25881960 | 0.77 | MAP3K5 (0.54) | MAP3K5 | |
| SCHEMBL25879550 | 0.77 | MAP3K5 (0.54) | MAP3K5CDK2 | |
| SCHEMBL25880004 | 0.76 | SYK (0.45) | MAP3K5 | |
| SCHEMBL30512121 | 0.75 | BRAF (0.46) | MAP3K5AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023138412-A1 | FUSED PYRIMIDIN-2-AMINE COMPOUNDS AS CDK20 INHIBITORS | INSILICO MEDICINE IP LIMITED (CN) | 2023-07-27 | — | — | WO | disclosed |