Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 9/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | WEE1 | P30291 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25880449 | 0.87 | HRH4 (0.53) | HRH4HRH3MAP3K5CDK2 | |
| SCHEMBL25880000 | 0.83 | BRAF (0.46) | MAP3K5MAP4K1PDGFRBPDGFRA | |
| SCHEMBL30512121 | 0.83 | BRAF (0.46) | MAP3K5MAP4K1PDGFRBPDGFRA | |
| SCHEMBL25882002 | 0.82 | EGFR (0.48) | MAP3K5SYKMAP4K1CDK2WEE1 | |
| SCHEMBL30512114 | 0.82 | EGFR (0.48) | MAP3K5SYKMAP4K1CDK2WEE1 | |
| SCHEMBL25880004 | 0.80 | SYK (0.45) | MAP3K5SYKMAP4K1 | |
| SCHEMBL30512136 | 0.80 | MAP3K5 (0.54) | MAP3K5CDK2 | |
| SCHEMBL25881961 | 0.80 | MAP3K5 (0.54) | MAP3K5CDK2 | |
| SCHEMBL30512112 | 0.79 | MAP3K5 (0.54) | MAP3K5SYKCDK2 | |
| SCHEMBL25879550 | 0.79 | MAP3K5 (0.54) | MAP3K5SYKCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023138412-A1 | FUSED PYRIMIDIN-2-AMINE COMPOUNDS AS CDK20 INHIBITORS | INSILICO MEDICINE IP LIMITED (CN) | 2023-07-27 | — | — | WO | disclosed |