Flumetramide

Flumetramide

SCHEMBL258835

O=C1COC(c2ccc(C(F)(F)F)cc2)CN1

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PRKAB2 O43741 1/20 0.43
PRKAG1 P54619 1/20 0.43
PRKAA2 P54646 1/20 0.43
PRKAA1 Q13131 1/20 0.43
PRKAG3 Q9UGI9 1/20 0.43
PRKAG2 Q9UGJ0 1/20 0.43
PRKAB1 Q9Y478 1/20 0.43
HTR1A P08908 1/20 0.40
PARP1 P09874 1/20 0.39
PARP2 Q9UGN5 1/20 0.39
HTR2C P28335 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flumetramide SCHEMBL9576017 1.00 PRKAB2 (0.43) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL28535518 0.85 HTR1A (0.42) HTR1APARP1PARP2HTR2C
SCHEMBL2299466 0.82 PRKAB2 (0.45) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL2296542 0.82 PRKAB2 (0.45) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL18742045 0.82 PRKAB2 (0.45) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL15301051 0.80 PRKAB2 (0.46) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL8192120 0.80 PRKAB2 (0.46) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL25181383 0.79 PRKAB2 (0.51) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL21779357 0.79 PRKAB2 (0.45) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL18741907 0.79 HTR1A (0.39) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1403 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-204969991-U Dual -use multi -functional quick detach both shoulders knapsack JIHUA 3502 PROFESSIONAL GARMENT CO LTD 2016-01-20 CN claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
EP-1478648-B1 PHOSPHORUS-CONTAINING COMPOUNDS AND USES THEREOF ARIAD PHARMA INC (US) 2014-04-30 EP claimed
US-8539862-B1 Buckle release tool MiiG Enterprises, Inc. (US) 2013-09-24 US claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
CN-1646537-A Phosphorus-containing compounds and their use ARIAD GENE THERAPEUTICS INC (US) 2005-07-27 CN claimed
US-20050032825-A1 Phosphorus-containing compounds and uses thereof MEDINOL LTD. (IL) 2005-02-10 US claimed
EP-1478648-A2 PHOSPHORUS-CONTAINING COMPOUNDS USES THEREOF ARIAD GENE THERAPEUTICS, INC. (US) 2004-11-24 EP claimed
US-20040073024-A1 Phosphorus-containing compounds and uses thereof ARIAD GENE THERAPEUTICS, INC. 2004-04-15 US claimed
US-20030220297-A1 Phosphorus-containing compounds and uses thereof ARIAD GENE THERAPEUTICS, INC. 2003-11-27 US claimed
WO-2003064383-A2 PHOSPHORUS-CONTAINING COMPOUNDS & USES THEREOF ARIAD GENE THERAPEUTICS, INC. (US) 2003-08-07 WO claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030220297-A1 Phosphorus-containing compounds and uses thereof NR5A2, NR2C2, NR2E1 PRKAB2 2121/4885PRKAG1 2455/4885PRKAA2 1944/4885
US-20040073024-A1 Phosphorus-containing compounds and uses thereof NR5A2, VDR, NR5A1 PRKAB2 1436/4885PRKAG1 1949/4885PRKAA2 1562/4885
US-20050032825-A1 Phosphorus-containing compounds and uses thereof NR5A2, NR2E3, VDR PRKAB2 1196/4885PRKAG1 1905/4885PRKAA2 1519/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.