Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2589397 | 0.84 | OPRK1 (0.38) | TDO2POLB | |
| SCHEMBL2592105 | 0.78 | PRKAB2 (0.41) | HCAR2DHODHAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL31404482 | 0.77 | HCAR2 (0.39) | HCAR2AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL29951743 | 0.74 | AKR1C3 (0.38) | HCAR2DHODHAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL2592544 | 0.72 | PPARA (0.40) | HCAR2DHODHAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL25257799 | 0.70 | HCAR2 (0.37) | HCAR2EPHX2 | |
| SCHEMBL30228865 | 0.70 | HCAR2 (0.37) | HCAR2EPHX2 | |
| SCHEMBL20135394 | 0.67 | KDM4E (0.48) | TDO2HSD17B10MAPTKDM4EMEN1 | |
| SCHEMBL700033 | 0.67 | CHRNA7 (0.40) | MEN1KMT2A | |
| SCHEMBL20568350 | 0.67 | HCAR2 (0.42) | HCAR2CCNA2CDK2CCNA1KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566328-A1 | INDAZOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140325-A1 | INDAZOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | disclosed |