Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 7/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594455 | 0.82 | PPARA (0.40) | PPARAHCAR3HCAR2AKR1C4AKR1C3 | |
| SCHEMBL29951743 | 0.75 | AKR1C3 (0.38) | HCAR2AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL2588883 | 0.72 | HCAR2 (0.39) | PPARAHCAR2AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL2592029 | 0.72 | MCL1 (0.41) | POLB | |
| SCHEMBL2592617 | 0.68 | MAP2K4 (0.41) | — | |
| SCHEMBL2593108 | 0.68 | NQO2 (0.40) | HSD17B10 | |
| SCHEMBL30123024 | 0.68 | HCAR3 (0.35) | PPARAHCAR3HCAR2PPARGPOLB | |
| SCHEMBL17970547 | 0.66 | AKR1C3 (0.41) | AKR1C4AKR1C3AKR1C2AKR1C1DHODH | |
| SCHEMBL6231360 | 0.65 | HCAR3 (0.39) | PPARAHCAR3HCAR2HSD17B10POLB | |
| SCHEMBL11886213 | 0.65 | PDPK1 (0.58) | DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566328-A1 | INDAZOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140325-A1 | INDAZOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | disclosed |