Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.36 |
| ▸ | AXL | P30530 | 4/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.36 |
| ▸ | MERTK | Q12866 | 3/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | ABL2 | P42684 | 1/20 | 0.36 |
| ▸ | FRK | P42685 | 1/20 | 0.36 |
| ▸ | MST1R | Q04912 | 1/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588943 | 0.82 | MET (0.36) | METAXLTYRO3MERTKLCK | |
| SCHEMBL14975552 | 0.79 | MET (0.44) | METAXLKDRNTRK1PDGFRA | |
| SCHEMBL14975545 | 0.79 | MET (0.47) | METAXLMERTKKDRNTRK1 | |
| SCHEMBL14975035 | 0.78 | MET (0.42) | METAXLKDRNTRK1NTRK2 | |
| SCHEMBL14975389 | 0.78 | MET (0.46) | METAXLTYRO3MERTKKDR | |
| SCHEMBL14975314 | 0.77 | KDR (0.48) | METAXLTYRO3MERTKKDR | |
| SCHEMBL14977826 | 0.77 | MET (0.34) | METAXLTYRO3MERTKLCK | |
| SCHEMBL2577143 | 0.76 | MET (0.53) | METAXLTYRO3MERTKLCK | |
| SCHEMBL14976417 | 0.73 | MET (0.44) | METAXLTYRO3MERTKLCK | |
| SCHEMBL14975674 | 0.72 | MET (0.38) | METAXLTYRO3MERTKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563773-A1 | PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITES | Deciphera Pharmaceuticals, LLC (US) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011139891-A1 | PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2011-11-10 | — | — | WO | disclosed |