Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PER2 | O15055 | 1/20 | 0.34 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2596039 | 0.72 | HCRTR1 (0.54) | HCRTR1HCRTR2MAPTPOLBALDH1A1 | |
| SCHEMBL2588933 | 0.72 | HCRTR2 (0.56) | HCRTR1HCRTR2AGTR1MAPTPOLB | |
| SCHEMBL1906715 | 0.69 | POLB (0.55) | MAPTPOLBALDH1A1KDM4ELMNA | |
| SCHEMBL3373253 | 0.65 | P2RX4 (0.47) | MAPTPOLBALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL2594552 | 0.65 | HCRTR1 (0.52) | HCRTR1HCRTR2MAPTPOLBALDH1A1 | |
| SCHEMBL2592911 | 0.65 | HCRTR2 (0.54) | HCRTR1HCRTR2MAPTPOLBALDH1A1 | |
| SCHEMBL2592992 | 0.64 | ATM (0.57) | HCRTR1HCRTR2MAPTPOLBALDH1A1 | |
| SCHEMBL498618 | 0.64 | KMT2A (0.53) | MAPTALDH1A1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL2588315 | 0.64 | L3MBTL1 (0.65) | HCRTR1HCRTR2MAPTPOLBALDH1A1 | |
| SCHEMBL5316843 | 0.63 | MAOB (0.50) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |