Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 4/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588933 | 0.88 | HCRTR2 (0.56) | HCRTR2HCRTR1MAPTALDH1A1POLB | |
| SCHEMBL2594552 | 0.78 | HCRTR1 (0.52) | HCRTR2HCRTR1MAPTALDH1A1POLB | |
| SCHEMBL7708409 | 0.78 | HCRTR1 (0.68) | HCRTR2HCRTR1ALDH1A1KMT2AMEN1 | |
| SCHEMBL29092151 | 0.78 | HCRTR1 (0.56) | HCRTR2HCRTR1MAPTALDH1A1POLB | |
| SCHEMBL7708626 | 0.74 | HCRTR1 (0.71) | HCRTR2HCRTR1MAPTALDH1A1POLB | |
| SCHEMBL2592524 | 0.71 | POLB (0.53) | HCRTR2HCRTR1MAPTALDH1A1POLB | |
| SCHEMBL2592641 | 0.70 | L3MBTL1 (0.62) | HCRTR2HCRTR1MAPTALDH1A1POLB | |
| SCHEMBL7704867 | 0.70 | HCRTR2 (1.00) | HCRTR2HCRTR1MAPTALDH1A1POLB | |
| SCHEMBL7707974 | 0.69 | HCRTR2 (0.53) | HCRTR2HCRTR1ALDH1A1POLBKMT2A | |
| SCHEMBL28546173 | 0.68 | POLB (0.44) | MAPTALDH1A1POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |