Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2596039 | 0.91 | HCRTR1 (0.54) | ATMPOLBLMNATHRBL3MBTL1 | |
| SCHEMBL2588315 | 0.89 | L3MBTL1 (0.65) | ATMPOLBLMNATHRBL3MBTL1 | |
| SCHEMBL2592524 | 0.88 | POLB (0.53) | ATMPOLBLMNATHRBL3MBTL1 | |
| SCHEMBL2594552 | 0.80 | HCRTR1 (0.52) | ATMPOLBLMNATHRBL3MBTL1 | |
| SCHEMBL2592641 | 0.78 | L3MBTL1 (0.62) | ATMPOLBLMNATHRBL3MBTL1 | |
| SCHEMBL2592990 | 0.77 | POLB (0.74) | ATMPOLBLMNATHRBMAPT | |
| SCHEMBL2592528 | 0.76 | POLB (0.69) | ATMPOLBLMNATHRBL3MBTL1 | |
| SCHEMBL8089258 | 0.73 | MEN1 (0.50) | POLBMAPTTP53KDM4EMEN1 | |
| SCHEMBL7703516 | 0.70 | HCRTR1 (0.90) | ATMPOLBLMNATHRBMAPT | |
| SCHEMBL7703511 | 0.70 | HCRTR1 (0.90) | ATMPOLBLMNATHRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |