Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 12/20 | 0.48 |
| ▸ | HTR2A | P28223 | 12/20 | 0.48 |
| ▸ | HTR7 | P34969 | 12/20 | 0.48 |
| ▸ | HTR6 | P50406 | 12/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6635126 | 0.92 | HTR1A (0.49) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL9963282 | 0.91 | OPRM1 (0.54) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL26025784 | 0.84 | OPRM1 (0.56) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL6634008 | 0.82 | HTR1A (0.48) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL6635753 | 0.81 | HTR1A (0.53) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL29387092 | 0.81 | BACE1 (0.64) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL1268479 | 0.81 | BACE1 (0.64) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL2265580 | 0.81 | BACE1 (0.64) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL29609089 | 0.81 | BACE1 (0.64) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| Hydrochloric Acid SCHEMBL6639305 | 0.81 | HTR1A (0.45) | OPRM1OPRK1OPRL1BACE1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | HERCULES CAPITAL, INC., AS AGENT | 2023-08-24 | — | — | US | disclosed |
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | HERCULES CAPITAL, INC., AS AGENT | 2023-08-24 | — | — | US | disclosed |
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | APOL1, APOB, LDLR | OPRM1 683/4885OPRK1 1495/4885OPRL1 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.