Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASEH1 | O60930 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TYR | P14679 | 3/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17026838 | 0.86 | TRPA1 (0.48) | RNASEH1HSP90AA1HSP90AB1ALDH1A1HTT | |
| SCHEMBL12172236 | 0.84 | ALDH1A1 (0.50) | RNASEH1HSP90AA1HSP90AB1ALDH1A1HTT | |
| SCHEMBL25906333 | 0.83 | HSP90AA1 (0.49) | RNASEH1HSP90AA1HSP90AB1ALDH1A1HTT | |
| SCHEMBL12035991 | 0.82 | ALDH1A1 (0.47) | RNASEH1HSP90AA1HSP90AB1ALDH1A1HTT | |
| SCHEMBL5167176 | 0.81 | RNASEH1 (0.55) | RNASEH1HSP90AA1HSP90AB1ALDH1A1HTT | |
| SCHEMBL19289761 | 0.81 | SMN1; SMN2 (0.40) | RNASEH1HSP90AA1HSP90AB1ALDH1A1HTT | |
| SCHEMBL29260542 | 0.80 | ALDH1A1 (0.48) | RNASEH1HSP90AA1HSP90AB1ALDH1A1HTT | |
| SCHEMBL50460 | 0.79 | ALDH1A1 (0.55) | RNASEH1HSP90AA1HSP90AB1ALDH1A1HTT | |
| SCHEMBL25906366 | 0.78 | RNASEH1 (0.41) | RNASEH1HSP90AA1HSP90AB1ALDH1A1HTT | |
| SCHEMBL24535921 | 0.77 | AGBL2 (0.40) | RNASEH1HSP90AA1HSP90AB1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-08-01 | — | — | US | disclosed |
| US-8999966-B2 | Compounds that are ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-04-07 | — | — | US | disclosed |
| US-20130237518-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME CORP | 2013-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130237518-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MAPK1, MAPK4, MAP3K20 | RNASEH1 3690/4885HSP90AA1 1983/4885HSP90AB1 1077/4885 |
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | AAAS, PROC, AADAC | RNASEH1 2502/4885HSP90AA1 1344/4885HSP90AB1 1341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.