Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 4/20 | 0.43 |
| ▸ | CHKB | Q9Y259 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13955431 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MAPK1CYP3A4TSHRTDP1 | |
| SCHEMBL21730035 | 0.79 | GAA (0.43) | ALDH1A1CYP3A4TSHRMEN1KMT2A | |
| SCHEMBL15144852 | 0.74 | AOC3 (0.44) | ALDH1A1MAPK1CYP3A4TSHRTDP1 | |
| SCHEMBL346292 | 0.74 | ALDH1A1 (0.61) | ALDH1A1MAPK1CYP3A4TSHRTDP1 | |
| SCHEMBL2679725 | 0.74 | ESR1 (0.58) | ALDH1A1CYP3A4CALM1SIGMAR1 | |
| SCHEMBL19146968 | 0.73 | SIGMAR1 (0.50) | SIGMAR1PYCR1IDO1HTR2A | |
| SCHEMBL22930079 | 0.72 | ESR1 (0.43) | CHKAALDH1A1MAPK1CYP3A4TSHR | |
| Hydrochloric Acid SCHEMBL2861214 | 0.72 | ALDH1A1 (0.58) | ALDH1A1MAPK1CYP3A4TSHRTDP1 | |
| SCHEMBL6310153 | 0.72 | ALDH1A1 (0.64) | CHKACHKBALDH1A1MAPK1CYP3A4 | |
| SCHEMBL3359190 | 0.72 | PPARG (0.44) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234950-A1 | CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234950-A1 | CRBN LIGANDS AND USES THEREOF | CRBN, CRKL, ERBB3 | CHKA 1169/4885CHKB 973/4885ALDH1A1 4145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.