Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dapsone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.73 |
| ▸ | TSHR | P16473 | 3/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | MPO | P05164 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dapsone SCHEMBL1219599 | 0.85 | HTR6 (1.00) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL21428 | 0.85 | HTR6 (1.00) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL5055312 | 0.85 | HTR6 (1.00) | HTR6TSHRCYP3A4LMNAMPO | |
| SCHEMBL324893 | 0.85 | HTR6 (1.00) | HTR6TSHRCYP3A4LMNAMPO | |
| SCHEMBL10596934 | 0.85 | HTR6 (1.00) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL2203636 | 0.83 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL9690505 | 0.83 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL9690514 | 0.83 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL11745790 | 0.83 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL28520980 | 0.83 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563121-A1 | METHODS AND COMPOSITIONS FOR PROTECTING AGAINST NEUROTOXIC AGENTS | Revalesio Corporation (US) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011137317-A1 | METHODS AND COMPOSITIONS FOR PROTECTING AGAINST NEUROTOXIC AGENTS | REVALESIO CORPORATION (US) | 2011-11-03 | — | — | WO | disclosed |