Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.39 |
| ▸ | GRK2 | P25098 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | EIF4EBP1 | Q13541 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25908025 | 0.88 | EIF4EBP1 (0.39) | GRK2ACHEEIF4EBP1TNFDRD2 | |
| SCHEMBL25908034 | 0.87 | DRD2 (0.40) | GRK2ACHEEIF4EBP1TNFDRD2 | |
| SCHEMBL25907893 | 0.87 | TIPARP (0.36) | TIPARPGRK2ACHEEIF4EBP1TNF | |
| SCHEMBL25899259 | 0.86 | NPC1 (0.42) | TIPARPGRK2EIF4EBP1TNF | |
| SCHEMBL25908040 | 0.82 | TIPARP (0.37) | TIPARPGRK2EIF4EBP1TNF | |
| SCHEMBL25907877 | 0.81 | TIPARP (0.44) | TIPARPGRK2ACHEEIF4EBP1TNF | |
| SCHEMBL25907670 | 0.78 | ACHE (0.41) | GRK2ACHEEIF4EBP1 | |
| SCHEMBL25907905 | 0.77 | ACHE (0.39) | GRK2ACHEEIF4EBP1DRD2DRD3 | |
| SCHEMBL25899268 | 0.77 | NPC1 (0.41) | GRK2TNF | |
| SCHEMBL25324913 | 0.75 | TIPARP (0.59) | TIPARP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023147418-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2023-08-03 | — | — | WO | disclosed |