Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.56 |
| ▸ | RXRB | P28702 | 1/20 | 0.56 |
| ▸ | RXRG | P48443 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.48 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6908239 | 0.87 | RXRA (0.49) | RXRARXRBRXRGPTGS2PTPN5 | |
| SCHEMBL9656296 | 0.86 | PTGS2 (0.48) | RXRARXRBRXRGPTGS2PTPN5 | |
| SCHEMBL17809807 | 0.86 | PTPN5 (0.51) | RXRARXRBRXRGPTGS2PTPN5 | |
| SCHEMBL13524587 | 0.85 | RXRA (0.56) | RXRARXRBRXRGPTPN5CYP2A6 | |
| SCHEMBL598181 | 0.84 | RXRA (0.66) | RXRARXRBRXRGPTPN5CTSS | |
| SCHEMBL13524585 | 0.84 | RXRA (0.58) | RXRARXRBRXRGPTGS2PTPN5 | |
| SCHEMBL5355878 | 0.82 | RXRA (0.65) | RXRARXRBRXRGPTGS2PTPN5 | |
| SCHEMBL29727265 | 0.82 | RXRA (0.65) | RXRARXRBRXRGPTGS2PTPN5 | |
| SCHEMBL11326904 | 0.82 | BCL2 (0.53) | PTGS2BCL2CYP1A2CYP2A6TAAR1 | |
| Ethane SCHEMBL6908245 | 0.82 | RXRA (0.63) | RXRARXRBRXRGPTPN5CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | AAAS, PROC, AADAC | RXRA 2013/4885RXRB 1550/4885RXRG 1124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.