Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 2/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.53 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12057532 | 0.88 | KLKB1 (0.71) | KLKB1MAPK11MAPK14HPGDSALKBH2 | |
| SCHEMBL25910310 | 0.83 | KLKB1 (0.80) | KLKB1 | |
| SCHEMBL2605693 | 0.79 | HPGDS (0.62) | HPGDSALKBH2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL27645860 | 0.77 | HPGDS (0.64) | HPGDSALKBH2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL25910329 | 0.76 | LMNA (0.65) | KLKB1SMN1; SMN2HPGD | |
| SCHEMBL4903546 | 0.74 | HPGDS (0.68) | HPGDSALKBH2SMN1; SMN2NPC1RAB9A | |
| Acetic Acid SCHEMBL29253713 | 0.73 | KLKB1 (0.66) | KLKB1MAPK11MAPK14HPGDSSMN1; SMN2 | |
| Acetic Acid SCHEMBL29253774 | 0.73 | KLKB1 (0.94) | KLKB1 | |
| SCHEMBL25910325 | 0.73 | NPC1 (0.61) | NPC1RAB9AHDAC1HPGD | |
| SCHEMBL31023522 | 0.73 | EPHX2 (0.60) | KLKB1MAPK11MAPK14HPGDSALKBH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234927-A1 | PROCESSES FOR PREPARING PLASMA KALLIKREIN INHIBITORS | REZOLUTE INC (US) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234927-A1 | PROCESSES FOR PREPARING PLASMA KALLIKREIN INHIBITORS | C1R, C1S, KLKB1 | KLKB1 3/4885MAPK11 3049/4885MAPK14 3786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.