Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 7/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.54 |
| ▸ | TUBB | P07437 | 1/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.54 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.54 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.54 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.54 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25910928 | 0.88 | HPGD (0.54) | KDM4ERAB9AHPGDNPC1SMN1; SMN2 | |
| SCHEMBL25910932 | 0.88 | SMN1; SMN2 (0.63) | KDM4ERAB9AHPGDNPC1SMN1; SMN2 | |
| SCHEMBL25911115 | 0.87 | TUBB4A (0.69) | KDM4ERAB9AHPGDNPC1SMN1; SMN2 | |
| SCHEMBL25910967 | 0.85 | TUBB4A (0.54) | KDM4ERAB9AHPGDNPC1SMN1; SMN2 | |
| SCHEMBL25910937 | 0.85 | ALDH1A1 (0.73) | KDM4ERAB9AHPGDNPC1SMN1; SMN2 | |
| SCHEMBL312000 | 0.84 | HPGD (0.61) | KDM4ERAB9AHPGDNPC1SMN1; SMN2 | |
| SCHEMBL29902940 | 0.82 | TUBB4A (0.80) | KDM4ERAB9AHPGDNPC1SMN1; SMN2 | |
| SCHEMBL22552099 | 0.82 | TUBB4A (0.80) | KDM4ERAB9AHPGDNPC1SMN1; SMN2 | |
| SCHEMBL15223801 | 0.81 | HDAC6 (0.53) | HSD17B1 | |
| SCHEMBL25911109 | 0.80 | MAPT (0.60) | KDM4ERAB9AHPGDNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230233549-A1 | METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES | ACADEMIA SINICA (TW) | 2023-07-27 | — | — | US | disclosed |
| US-11638705-B2 | 4(1H)-quinolone derivatives and uses thereof | ACADEMIA SINICA (TW) | 2023-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11638705-B2 | 4(1H)-quinolone derivatives and uses thereof | TUBB1, TUBB3, TUBB | KDM4E 4231/4885RAB9A 1780/4885HPGD 794/4885 |
| US-20230233549-A1 | METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES | TUBB1, TUBB3, TUBB | KDM4E 4301/4885RAB9A 1690/4885HPGD 1023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.