Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.47 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.47 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.47 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25911152 | 0.87 | TP53 (0.54) | ALDH1A1PKMMAPK1HDAC8TP53 | |
| SCHEMBL25910972 | 0.84 | ALDH1A1 (0.53) | ALDH1A1MAPK1HDAC8TP53KMT2A | |
| SCHEMBL25911142 | 0.84 | ALDH1A1 (0.53) | ALDH1A1PKMMAPK1HDAC8LMNA | |
| SCHEMBL25911149 | 0.81 | ALDH1A1 (0.50) | ALDH1A1PKMMAPK1HDAC8KMT2A | |
| SCHEMBL25910983 | 0.80 | KDM4E (0.52) | ALDH1A1MAPK1HDAC8FNTAFNTB | |
| SCHEMBL25911025 | 0.80 | GPBAR1 (0.52) | ALDH1A1MAPK1HDAC8TP53FNTA | |
| SCHEMBL25911014 | 0.79 | PDK1 (0.52) | ALDH1A1MAPK1HDAC8LMNA | |
| SCHEMBL25911165 | 0.78 | ALDH1A1 (0.49) | ALDH1A1MAPK1HDAC8TP53KMT2A | |
| SCHEMBL25911127 | 0.78 | ALDH1A1 (0.51) | ALDH1A1MAPK1HDAC8KMT2ALMNA | |
| SCHEMBL25911163 | 0.78 | ALDH1A1 (0.48) | ALDH1A1PKMMAPK1HDAC8TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230233541-A1 | SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230233541-A1 | SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230233541-A1 | SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1 | TREH, BRIX1, GBA1 | ALDH1A1 327/4885PKM 2240/4885TBXAS1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.