Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.63 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.63 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | FASN | P49327 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752745 | 0.79 | PLA2G2A (0.96) | PLA2G2APLA2G5FFAR1ALDH1A1MAPT | |
| SCHEMBL9752630 | 0.78 | PLA2G2A (1.00) | PLA2G2APLA2G5FFAR1ALDH1A1MAPT | |
| SCHEMBL9752639 | 0.78 | PLA2G2A (1.00) | PLA2G2APLA2G5FFAR1ALDH1A1MAPT | |
| SCHEMBL9752731 | 0.78 | PLA2G2A (1.00) | PLA2G2APLA2G5FFAR1ALDH1A1MAPT | |
| SCHEMBL9752640 | 0.73 | PLA2G2A (0.85) | PLA2G2APLA2G5FFAR1ALDH1A1MAPT | |
| SCHEMBL21523095 | 0.73 | PLA2G2A (0.45) | PLA2G2APLA2G5FFAR1ALDH1A1MAPT | |
| SCHEMBL31691183 | 0.73 | PLA2G2A (0.45) | PLA2G2APLA2G5FFAR1ALDH1A1MAPT | |
| SCHEMBL23151040 | 0.72 | PLA2G2A (0.48) | PLA2G2APLA2G5FFAR1ALDH1A1MAPT | |
| SCHEMBL21552582 | 0.72 | PLA2G2A (0.48) | PLA2G2APLA2G5FFAR1ALDH1A1MAPT | |
| SCHEMBL21552430 | 0.72 | PLA2G2A (0.48) | PLA2G2APLA2G5FFAR1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219912-A1 | HALOGENATED BENZOTHIADIAZINES FOR THE TREATMENT OF CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219912-A1 | HALOGENATED BENZOTHIADIAZINES FOR THE TREATMENT OF CANCER | TFAM, NDUFAF1, NDUFV1 | PLA2G2A 3659/4885PLA2G5 3070/4885FFAR1 2557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.