Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | G6PD | P11413 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4745055 | 0.88 | MAPT (0.56) | MAPK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL12776990 | 0.83 | MAPK1 (0.53) | MAPK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL3913230 | 0.81 | CDC25C (0.49) | MAPK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL4748364 | 0.80 | MAPT (0.57) | MAPK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL28825199 | 0.80 | ALDH1A1 (0.46) | MAPK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL25863237 | 0.80 | ALDH1A1 (0.46) | MAPK1MAPTKDM4EKMT2AALDH1A1 | |
| SCHEMBL3921406 | 0.80 | ALDH1A1 (0.49) | MAPK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL31423166 | 0.80 | CYP1A2 (0.49) | MAPK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL8679011 | 0.80 | MAPK1 (0.49) | MAPK1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL8458580 | 0.80 | MAPT (0.49) | MAPK1MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220135544-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2022-05-05 | — | — | US | disclosed |
| US-20200131153-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2020-04-30 | — | — | US | disclosed |
| EP-3178818-B1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2019-05-22 | — | — | EP | disclosed |
| US-20180127397-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2018-05-10 | — | — | US | disclosed |
| US-9850228-B2 | Pyrazolyl quinoxaline kinase inhibitors | ASTEX THERAPEUTICS LTD (GB) | 2017-12-26 | — | — | US | disclosed |
| EP-3178818-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | Astex Therapeutics Limited (GB) | 2017-06-14 | — | — | EP | disclosed |
| EP-2563775-B1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2017-01-04 | — | — | EP | disclosed |
| US-20160311800-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2016-10-27 | — | — | US | disclosed |
| US-9464071-B2 | Pyrazolyl quinoxaline kinase inhibitors | ASTEX THERAPEUTICS LTD (GB) | 2016-10-11 | — | — | US | disclosed |
| CN-104725362-A | PYRAZOLYL QUINAZOLINE KINASE INHIBITORS | ASTEX THERAPEUTICS LTD | 2015-06-24 | — | — | CN | disclosed |
| US-20150105368-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2015-04-16 | — | — | US | disclosed |
| CN-102858765-B | Pyrazolyl quinoxaline kinase inhibitors | ASTEX THERAPEUTICS LTD | 2015-04-01 | — | — | CN | disclosed |
| US-8895601-B2 | Pyrazolyl quinoxaline kinase inhibitors | ASTEX THERAPEUTICS LTD (GB) | 2014-11-25 | — | — | US | disclosed |
| US-20130072457-A1 | PYRAZOLYL QUINAZOLINE KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2013-03-21 | — | — | US | disclosed |
| EP-2563775-A1 | PYRAZOLYL QUINAZOLINE KINASE INHIBITORS | Astex Therapeutics Limited (GB) | 2013-03-06 | — | — | EP | disclosed |
| CN-102858765-A | Pyrazolyl quinazoline kinase inhibitors | ASTEX THERAPEUTICS LTD | 2013-01-02 | — | — | CN | disclosed |
| WO-2011135376-A1 | PYRAZOLYL QUINAZOLINE KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2011-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200131153-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | PDXK, DCK, PDPK1 | MAPK1 290/4885MAPT 1957/4885KDM4E 1300/4885 |
| US-20130072457-A1 | PYRAZOLYL QUINAZOLINE KINASE INHIBITORS | MAP3K5, MAP3K1, MAP4K2 | MAPK1 232/4885MAPT 1617/4885KDM4E 1334/4885 |
| US-20150105368-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | PDXK, DCK, PDPK1 | MAPK1 290/4885MAPT 1957/4885KDM4E 1300/4885 |
| US-20180127397-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | PDXK, DCK, PDPK1 | MAPK1 290/4885MAPT 1957/4885KDM4E 1300/4885 |
| US-20220135544-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | PDXK, DCK, PDPK1 | MAPK1 290/4885MAPT 1957/4885KDM4E 1300/4885 |
| US-20160311800-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | PDXK, DCK, PDPK1 | MAPK1 290/4885MAPT 1957/4885KDM4E 1300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.