SCHEMBL25920262

SCHEMBL25920262

CN(C)C1CCN(C2CCN(C(=O)c3ccc(Cl)c(N4CCC(=O)NC4=O)c3)CC2)CC1

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL3 Q96JM7 11/20 0.53
▸ L3MBTL1 Q9Y468 8/20 0.53
▸ LRRK2 Q5S007 1/20 0.45
▸ CCR3 P51677 4/20 0.42
▸ MBTD1 Q05BQ5 4/20 0.40
▸ TP53BP1 Q12888 2/20 0.40
▸ L3MBTL4 Q8NA19 1/20 0.40
▸ HDAC4 P56524 1/20 0.39
▸ HRH1 P35367 1/20 0.39
▸ CHRM1 P11229 2/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25920183 0.86 L3MBTL3 (0.43) L3MBTL3L3MBTL1KMT2A
SCHEMBL30014881 0.83 NPSR1 (0.51) KMT2A
SCHEMBL31161778 0.82 MEN1 (0.45) L3MBTL3L3MBTL1LRRK2HDAC4MEN1
SCHEMBL31161491 0.82 MEN1 (0.45) L3MBTL3L3MBTL1LRRK2HDAC4MEN1
SCHEMBL31255589 0.81 LRRK2 (0.42) L3MBTL3L3MBTL1LRRK2CCR3
Trifluoroacetic Acid SCHEMBL31161289 0.81 LRRK2 (0.43) L3MBTL3L3MBTL1LRRK2CCR3MBTD1
SCHEMBL26097569 0.81 LRRK2 (0.40) L3MBTL3L3MBTL1LRRK2MEN1KMT2A
SCHEMBL30392231 0.81 LRRK2 (0.40) L3MBTL3L3MBTL1LRRK2MEN1KMT2A
SCHEMBL29201743 0.79 MGLL (0.42) LRRK2MEN1KMT2A
SCHEMBL30015013 0.79 TSHR (0.43) CCR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230234936-A1 COMPOUND FOR TARGETING AND DEGRADING PROTEIN, AND PREPARATION METHOD THEREFOR AND USE THEREOF LEADINGTAC PHARMACEUTICAL (SHAOXING) CO., LTD. (CN) 2023-07-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230234936-A1 COMPOUND FOR TARGETING AND DEGRADING PROTEIN, AND PREPARATION METHOD THEREFOR AND USE THEREOF IRAK4, IRAK2, IRAK1 L3MBTL3 3485/4885L3MBTL1 2460/4885LRRK2 1018/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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