Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28978062 | 0.91 | MGLL (0.39) | MGLLHSD11B1HPGDPKMDDB1 | |
| SCHEMBL24670711 | 0.87 | HSD11B1 (0.43) | MGLLHSD11B1NPSR1DDB1CRBN | |
| SCHEMBL30995353 | 0.87 | DDB1 (0.46) | MGLLHSD11B1HPGDTSHRDDB1 | |
| SCHEMBL30014881 | 0.87 | NPSR1 (0.51) | MGLLHSD11B1HPGDTSHRNPSR1 | |
| SCHEMBL29201734 | 0.87 | MGLL (0.42) | MGLLHSD11B1HPGDTSHR | |
| SCHEMBL29201772 | 0.85 | HSD11B1 (0.39) | MGLLHSD11B1TSHR | |
| SCHEMBL31722472 | 0.85 | NR3C1 (0.43) | HSD11B1HPGDNPSR1MEN1KMT2A | |
| SCHEMBL25581205 | 0.85 | NR3C1 (0.43) | HSD11B1HPGDNPSR1MEN1KMT2A | |
| SCHEMBL31524299 | 0.85 | MGLL (0.41) | MGLLHSD11B1TSHR | |
| SCHEMBL30020819 | 0.84 | HPGD (0.55) | HSD11B1HPGDLRRK2PKMDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4606803-A1 | KRAS G12D DEGRADATION AGENT, AND PREPARATION METHOD AND USE THEREFOR | Leadingtac Pharmaceutical (Shaoxing) Co., Ltd. (CN) | 2025-08-27 | — | — | EP | disclosed |
| CN-118344348-A | Heterocyclic substituted quinazoline and preparation method and application thereof | 苏州泽璟生物制药股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |