Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592656 | 0.86 | HSD11B1 (0.39) | CYP19A1HSD11B1KMT2A | |
| SCHEMBL2588272 | 0.85 | GPR119 (0.40) | HSD11B1KMT2A | |
| SCHEMBL2586856 | 0.78 | GPR119 (0.40) | KMT2A | |
| SCHEMBL2594530 | 0.74 | KMT2A (0.39) | KMT2A | |
| SCHEMBL2595165 | 0.73 | KMT2A (0.40) | KMT2A | |
| SCHEMBL14919110 | 0.64 | MAPT (0.42) | CYP19A1HSD11B1 | |
| SCHEMBL14918957 | 0.63 | HSD11B1 (0.47) | CYP19A1HSD11B1KMT2A | |
| SCHEMBL2587023 | 0.61 | MAPT (0.36) | CYP19A1HSD11B1 | |
| SCHEMBL30486561 | 0.60 | OTUD7B (0.36) | — | |
| SCHEMBL17761478 | 0.58 | KCNH2 (0.35) | HSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595989-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2011140425-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-10 | — | — | WO | disclosed |