Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25924599 | 0.68 | IDO1 (0.30) | IDO1CYP2C9KCNH2 | |
| SCHEMBL25924494 | 0.68 | IDO1 (0.37) | IDO1CYP2C9KCNH2DRD2SLC6A4 | |
| SCHEMBL25924492 | 0.64 | DRD2 (0.33) | IDO1CYP2C9KCNH2DRD2SLC6A4 | |
| SCHEMBL24932847 | 0.64 | DRD2 (0.38) | IDO1CYP2C9KCNH2DRD2SLC6A4 | |
| SCHEMBL25924497 | 0.62 | KRAS (0.34) | IDO1CYP2C9KCNH2DRD2SLC6A4 | |
| SCHEMBL25924254 | 0.61 | DRD2 (0.35) | IDO1CYP2C9KCNH2DRD2SLC6A4 | |
| SCHEMBL12694266 | 0.57 | DPP4 (0.43) | KMT2A | |
| SCHEMBL30417861 | 0.57 | IDO1 (0.41) | IDO1DRD2SLC6A4KMT2AALDH1A1 | |
| SCHEMBL25924477 | 0.56 | DRD2 (0.34) | IDO1CYP2C9KCNH2DRD2SLC6A4 | |
| SCHEMBL26023919 | 0.56 | DRD2 (0.36) | IDO1CYP2C9KCNH2DRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |