Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25924467 | 0.89 | PRPS1 (0.36) | DRD2DRD3OPRM1OPRL1PRPS1 | |
| SCHEMBL30507264 | 0.89 | PRPS1 (0.36) | DRD2DRD3OPRM1OPRL1PRPS1 | |
| SCHEMBL25317133 | 0.89 | PRPS1 (0.36) | DRD2DRD3OPRM1OPRL1PRPS1 | |
| SCHEMBL25315918 | 0.80 | PRPS1 (0.30) | DRD2DRD3PRPS1 | |
| SCHEMBL30506769 | 0.80 | PRPS1 (0.30) | DRD2DRD3PRPS1 | |
| SCHEMBL26042063 | 0.80 | PRPS1 (0.30) | DRD2DRD3PRPS1 | |
| SCHEMBL26023918 | 0.79 | DRD2 (0.34) | DRD2DRD3OPRM1OPRL1CYP11B2 | |
| SCHEMBL25924497 | 0.79 | KRAS (0.34) | DRD2DRD3OPRM1OPRL1CYP11B2 | |
| SCHEMBL25924477 | 0.79 | DRD2 (0.34) | DRD2DRD3OPRM1OPRL1CYP11B2 | |
| SCHEMBL26023916 | 0.79 | DRD2 (0.34) | DRD2DRD3OPRM1OPRL1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | HERCULES CAPITAL, INC., AS AGENT | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | APOL1, APOB, LDLR | DRD2 4491/4885DRD3 3353/4885OPRM1 683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.