Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17048230 | 0.77 | AURKA (0.36) | OPRM1OPRL1HCAR1ALDH1A1TP53 | |
| SCHEMBL25924927 | 0.72 | PRPS1 (0.44) | HCAR1ABL1ALDH1A1TP53CYP2C9 | |
| SCHEMBL25922292 | 0.71 | — | — | |
| SCHEMBL25924607 | 0.71 | — | — | |
| SCHEMBL14250388 | 0.70 | EGFR (0.31) | — | |
| SCHEMBL31051166 | 0.70 | LMNA (0.40) | HCAR1ABL1ALDH1A1IDO1AURKA | |
| SCHEMBL25319216 | 0.68 | CYP2C9 (0.32) | CYP2C9IDO1KCNH2 | |
| SCHEMBL30506732 | 0.68 | CYP2C9 (0.32) | CYP2C9IDO1KCNH2 | |
| SCHEMBL25924914 | 0.68 | CYP2C9 (0.32) | CYP2C9IDO1KCNH2 | |
| SCHEMBL14250611 | 0.67 | ROCK1 (0.30) | CYP2C9IDO1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |