⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25924599 | 0.77 | IDO1 (0.30) | — | |
| SCHEMBL25924932 | 0.71 | OPRM1 (0.32) | — | |
| SCHEMBL25922292 | 0.66 | — | — | |
| SCHEMBL25924619 | 0.62 | IDO1 (0.38) | — | |
| SCHEMBL25924494 | 0.59 | IDO1 (0.37) | — | |
| SCHEMBL25924609 | 0.57 | IDH1 (0.30) | — | |
| SCHEMBL26023928 | 0.56 | — | — | |
| SCHEMBL26023927 | 0.54 | CNR2 (0.31) | — | |
| SCHEMBL31349488 | 0.54 | AAK1 (0.35) | — | |
| SCHEMBL25924254 | 0.53 | DRD2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |